Marine Drugs: Volume 5, 2007, Table of Contents

Anake Kijjoa ^1,2,*, Rawiwan Wattanadilok ^2,3, Nair Campos ², Maria São José Nascimento ⁴, Madalena Pinto ⁴ and Werner Herz ⁵
1 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
2 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
3 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand
4 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Faculdade de Farmácia, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal
5 Department of Chemistry and Biochemistry, The Florida State University, Tallahassee, FL 32306-4390, USA
* Author to whom correspondence should be addressed; Email: ankijjoa@icbas.up.pt
Received: 26 March 2007 / Accepted: 4 April 2007 / Published: 17 April 2007
Full Original Paper: Anticancer Activity Evaluation of Kuanoniamines A and C Isolated from the Marine Sponge Oceanapia sagittaria, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5, 6-22 (PDF format 126 K); DOI: 10.3390/md20070002

Open Access

Gerhard Bringmann ^1,*, Tobias A. M. Gulder ¹, Gerhard Lang ^1,2, Stefanie Schmitt ¹, Rüdiger Stöhr ², Jutta Wiese ², Kerstin Nagel ² and Johannes F. Imhoff ^2,*
1 Institut für Organische Chemie, Universität Würzburg, Am Hubland, D-97074 Würzburg, Germany
2 Marine Mikrobiologie, Leibniz-Institut für Meereswissenschaften, IFM-GEOMAR, Düsternbrooker Weg 20, D-24105 Kiel, Germany
* Authors to whom correspondence should be addressed; G.B. Tel. +49-931-8885323, Fax +49-931-8884755, E-mail: bringman@chemie.uni-wuerzburg.de; J.F.I. Tel. +49-431-6004450, Fax +49-431-6004452, E-mail: jimhoff@ifm-geomar.de
Dedicated to Prof. Dr. W.E.G. Müller on the occasion of his 65th birthday
Received: 29 May 2007/ Accepted: 21 June 2007 / Published: 25 June 2007
Full Original Paper: Large-Scale Biotechnological Production of the Antileukemic Marine Natural Product Sorbicillactone A
Mar. Drugs 2007, 5, 23-30 (PDF format 89 K); DOI: 10.3390/md20070003
(This paper belongs to Special Issue: Marine Natural Products as Anti-Cancer Agents, edited by Prof. Dr. Jordan K. Zjawiony)

Open Access

Baoquan Bao ^1,2, Ping Zhang ¹, Yoonmi Lee ¹, Jongki Hong ³, Chong-O. Lee ⁴ and Jee H. Jung ^1,*
1 College of Pharmacy, Pusan National University, Busan 609-735, Korea
2 College of Traditional Mongolian Medicine, Inner Mongolia University for the Nationalities, Tongliao Inner Mongolia 028000, China; E-mail: baobaoquan@yahoo.com.cn
3 College of Pharmacy, Kyung Hee University, Seoul 130-701, Korea
4 Korea Research Institute of Chemical Technology, Daejon 305-343, Korea
* Author to whom correspondence should be addressed. Tel., 82-51-510-2803; Fax: 82-51-513-6754; E-mail: jhjung@pusan.ac.kr
Received: 5 June 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
Full Original Paper: Monoindole Alkaloids from a Marine Sponge Spongosorites sp.
Mar. Drugs 2007, 5, 31-39 (PDF format 118 K); DOI: 10.3390/md20070004

Open Access

Rawiwan Wattanadilok ^1,3, Pichan Sawangwong ², Cátia Rodrigues ^4,6, Honorina Cidade ^4,6, Madalena Pinto ^4,6, Eugenia Pinto ^5,6, Artur Silva ⁷ and Anake Kijjoa ^3,8,*
1 Bangsaen Institute of Marine Science (BIMS), Burapha University, Bangsaen, Chonburi 20131, Thailand
2 Department of Aquatic Science, Faculty of Sciences, Burapha University, Bangsaen, Chonburi 20131, Thailand
3 Centro Interdisciplinar de Investigação Marinha e Ambiental (CIIMAR), Universidade do Porto, Rua dos Bragas 289, 4050-123 Porto, Portugal
4 Laboratório de Química Orgânica, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal
5 Laboratório de Microbiologia, Faculdade de Farmácia, Universidade do Porto, Rua Aníbal Cunha 164, 4050-047 Porto, Portugal
6 Centro de Estudos de Química Orgânica, Fitoquímica e Farmacologia da Universidade do Porto (CEQOFFUP), Rua Aníbal Cunha 164, 4050-047 Porto, Portugal
7 Departamento de Química, Universidade de Aveiro, 4810-1933 Aveiro, Portugal
8 ICBAS-Instituto de Ciências Biomédicas Abel Salazar, Universidade do Porto, 4099-003 Porto, Portugal
* Author to whom correspondence should be addressed; Email: ankijjoa@icbas.up.pt
Received: 31 May 2007 / Accepted: 23 June 2007 / Published: 25 June 2007
Full Original Paper: Antifungal Activity Evaluation of the Constituents of Haliclona baeri and Haliclona cymaeformis, Collected from the Gulf of Thailand
Mar. Drugs 2007, 5, 40-51 (PDF format 110 K); DOI: 10.3390/md20070005

Manuel Martínez-García ^1,*, Marta Díaz-Valdés ², Alfonso Ramos-Esplá ², Nélida Salvador ³, Patricia Lopez ¹, Eduardo Larriba ¹ and Josefa Antón ¹
1 División de Microbiología, Universidad de Alicante, 03080 Alicante, Spain
2 Departamento de Ciencias del Mar y Biología Aplicada, Universidad de Alicante, 03080 Alicante, Spain
3 Instituto Biomar, S. A. Pol. Ind. Edificio CEI 2.02, 24231 Onzonilla, León, Spain
* Author to whom correspondence should be addressed; E-mail: m.martinez@ua.es
Received: 18 June 2007 / Accepted: 17 July 2007 / Published: 19 July 2007
Full Original Paper: Cytotoxicity of the Ascidian Cystodytes dellechiajei Against Tumor Cells and Study of the Involvement of Associated Microbiota in the Production of Cytotoxic Compounds
Mar. Drugs 2007, 5, 52-70 (PDF format 213 K); DOI: 10.3390/md20070006
(This paper belongs to Special Issue: Bioactive Compounds from Marine Microorganisms, edited by Dr. Ipek Kurtboke)

Maya P. Singh ^1,*, Jeffrey E. Janso ¹ and Sean F. Brady ^2,†
1 Natural Products Research, Chemical and Screening Sciences, Wyeth Research, Pearl River, NY 10965, USA; E-mail: jansoj@wyeth.com
2 Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA
† Current address: Laboratory of Genetically Encoded Small Molecules, The Rockefeller University, New York, NY 10021; E-mail: sbrady@mail.rockefeller.edu
* Author to whom correspondence should be addressed; E-mail: singhm@wyeth.com
Received: 22 June 2007 / Accepted: 8 July 2007 / Published: 19 July 2007
Full Original Paper: Cytoskyrins and Cytosporones Produced by Cytospora sp. CR200: Taxonomy, Fermentation and Biological Activities
Mar. Drugs 2007, 5, 71-84 (PDF format 138 K); DOI: 10.3390/md20070007

Open Access

Serena Leone ¹, Alba Silipo ¹, Evgeny L.Nazarenko ², Rosa Lanzetta ¹, Michelangelo Parrilli ¹ and Antonio Molinaro ^1,*
1 Dipartimento di Chimica Organica e Biochimica, Università degli studi di Napoli “Federico II”, via Cintia 4, I-80126 Napoli, Italy
2 Pacific Institute of Bioorganic Chemistry, Far-East Branch of the Russian Academy of Sciences, 690022 Vladivostok-22, Russian Federation
* Author to whom correspondence should be addressed. E-mail: molinaro@unina.it. Fax: +39-081-674393.
Received: 27 August 2007/ Accepted: 17 September 2007 / Published: 19 September 2007
Review: Molecular Structure of Endotoxins from Gram-negative Marine Bacteria: An Update
Mar. Drugs 2007, 5, 85-112 (PDF format 177 K); DOI: 10.3390/md20070008
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Open Access

Alejandro M. S. Mayer ^1,*, Marcio Guzman ², Renee Peksa ³, Mary Hall ⁴, Michael J. Fay ⁵, Peer B. Jacobson ⁶, Anne M. Romanic ⁷ and Sarath P. Gunasekera ⁸
1 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA
2 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: Marcio.Guzman@mwumail.midwestern.edu
3 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: Renee.Peksa@mwumail.midwestern.edu
4 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: mhallx@midwestern.edu
5 Department of Pharmacology, Chicago College of Osteopathic Medicine, Midwestern University, 555 31st Street, Downers Grove, Illinois 60515, USA; E-mail: mfayxx@midwestern.edu
6 Abbott Laboratories, Abbott Park, Illinois 60064, USA; E-mail: peer.b.jacobson@abbott.com
7 GlaxoSmithKline Pharmaceuticals, Department of Cardiovascular Pharmacology, King of Prussia, Pennsylvania 19406, USA; E-mail: arnolda5@wyeth.com
8 Harbor Branch Oceanographic Institution, Division of Biomedical Marine Research, 5600 US 1 North, Fort Pierce, FL 34946, USA; E-mail: sgunaseker@HBOI.edu
* Author to whom the correspondence should be addressed; Tel. 630 515 6951; Fax 630 515 6295. Email: amayer@midwestern.edu.
Received: 24 August 2007 / Accepted: 20 September 2007 / Published: 24 September 2007
Full Original Paper: Differential Effects of Domoic Acid and E. coli Lipopolysaccharide on Tumor Necrosis Factor-α, Transforming Growth Factor-β1 and Matrix Metalloproteinase-9 Release by Rat Neonatal Microglia: Evaluation of the Direct Activation Hypothesis
Mar. Drugs 2007, 5, 113-135 (PDF format 749 K); DOI: 10.3390/md20070009
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Mar. Drugs 2007, 5, 136-150 (PDF format 99 K); DOI: 10.3390/md20070010
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Taiko Oda ^1,*, Weifang Wang ², Kazuyo Ukai ², Takahiro Nakazawa ² and Masataka Mochizuki ¹
1 Kyoritsu University of Pharmacy, Shibakoen, Minato-ku, Tokyo 105-8512, Japan
2 Tohoku Pharmaceutical University, Komatsushima, Aoba-ku, Sendai 981-8558, Japan
*Author to whom correspondence should be addressed: Tel. +81-3-5400-2497, Fax +81-3-5400-2497, E-mail: oda-ti@kyoritsu-ph.ac.jp
Received: 25 September 2007 / Accepted: 29 October 2007 / Published: 30 October 2007
Full Original Paper: A Sesquiterpene Quinone, 5-Epi-smenospongine, Promotes TNF-α Production in LPS-stimulated RAW 264.7 Cells

Tom Turk ¹, Robert Frangež ² and Kristina Sepčić ^1,*
1 Department of Biology, Biotechnical Faculty, University of Ljubljana, Večna pot 111, 1000 Ljubljana, Slovenia; e-mail: tom.turk@bf.uni-lj.si
2 Institute of Physiology, Pharmacology and Toxicology, Veterinary Faculty, Gerbičeva 60, University of Ljubljana, Slovenia; e-mail: robert.frangez@vf.uni-lj.si
* Author to whom correspondence should be addressed; e-mail: kristina.sepcic@bf.uni-lj.si; Fax: +38612573390, Tel: +38614233388.
Received: 16 October 2007 / Accepted: 31 October 2007 / Published: 13 November 2007
Review: Mechanisms of Toxicity of 3-Alkylpyridinium Polymers from Marine Sponge Reniera sarai

Mar. Drugs 2007, 5, 157-167 (PDF format 79 K); DOI: 10.3390/md20070012
(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Zouher Amzil ^1,*, Manoella Sibat ¹, Florence Royer ¹, Nadine Masson ² and Eric Abadie ³
1 IFREMER, Microbiology and Phycotoxins Department, BP 21105, 44311 Nantes, France; E-mails: Manoella.Sibat@ifremer.fr, Florence.Royer@ifremer.fr
2 IFREMER, station d’Arcachon, Quai du Cdt Silhouette, 33120, Arcachon, France; E-mail: Nadine.Masson@ifremer.fr,
3 IFREMER, station de Sète, Avenue Jean Monnet, BP 171, 34203, Sète, France; E-mail: Eric.Abadie@ifremer.fr
* Corresponding author: E-mail: Zouher.Amzil@ifremer.fr; Phone: (33) 2-40-37-40-69; Fax: (33) 2-40-37-40-73

Sandra Anne Banack ^1,2, Holly E. Johnson ¹, Ran Cheng ¹ and Paul Alan Cox ^1,*
1 Institute for Ethnomedicine, Box 3464, Jackson Hole, Wyoming 83001, USA; E-mails: sbanack@fullerton.edu (Sandra Anne Banack); holly@ethnomedicine.org (Holly E. Johnson);
ladianaus@hotmail.com (Ran Cheng)
2 Department of Biological Science, California State University, Fullerton, California 92834, USA
* Author to whom correspondence should be addressed; E-mail: paul@ethnomedicine.org
Received: November 17, 2007 / Accepted: 4 December 2007 / Published: 6 December 2007

(This paper belongs to Special Issue Marine Toxins edited by Dr. Alejandro Mayer)

Vipra Kundoor ¹, Xiaoying Zhang ¹, Ajay Bommareddy ¹, Sherief Khalifa ², Hesham Fahmy ^1,* and Chandradhar Dwivedi ¹
1 Department of Pharmaceutical Sciences, South Dakota State University, Box 2202C, Brookings, SD 57007, USA. Tel.: 605-688-4243, Fax 605-688-5993.
2 Department of Pharmacognosy, Faculty of Pharmacy, Suez Canal University, Ismailia, Egypt
* Author to whom correspondence should be addressed; E-mail: Hesham.Fahmy@sdstate.edu
Received: 2 October 2007 / Accepted: 11 December 2007 / Published: 12 December 2007
Full Research Paper: Chemopreventive Effects of Sarcotriol on Ultraviolet B-induced Skin Tumor Development in SKH-1 Hairless Mice

Lora E. Fleming ^1,*, Eva Jerez ², Wendy Blair Stephan ², Amy Cassedy ³, Judy A Bean ³, Andrew Reich ⁴, Barbara Kirkpatrick ⁵, Lorraine Backer ⁶, Kate Nierenberg ⁵, Sharon Watkins ⁴, Julie Hollenbeck ¹ and Richard Weisman ²
1 NSF NIEHS Oceans and Human Health Center, Rosenstiel School of Marine and Atmospheric Sciences, University of Miami, Miami, FL 33136 USA
2 South Florida Poison Information Center, Department of Pediatrics, Miller School of Medicine, University of Miami, and Jackson Health Systems, Miami, FL 33136 USA
3 Biostatistics, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45244 USA
4 Aquatic Toxins Group, Environmental Epidemiology, Florida Department of Health, Tallahassee, FL 32399-1712 USA
5 Mote Marine Laboratory, Sarasota, FL 34236 USA
6 National Center for Environmental Health (NCEH), Centers for Disease Control and Prevention (CDC), Atlanta, GA 30341 USA
* Author to whom correspondence should be addressed; e-mail: lfleming@med.miami.edu; mailing address: Departments of Epidemiology & Public Health and Marine Biology & Fisheries (MBF)
University of Miami School of Medicine and Rosenstiel School of Marine and Atmospheric Sciences (RSMAS), Clinical Research Building (CRB), 10th Floor (R 669), 1120 NW 14th Street, Miami, FL 33136, USA; Tel: +1 305 243 5912' Fax: +1 305 243 3384
Received: 30 October 2007 / Accepted: 12 December 2007 / Published: 14 December 2007

John P. Bowman
Tasmania Institute of Agricultural Research, School of Agricultural Science, University of Tasmania, Sandy Bay, Private Bag 54, Hobart, Tasmania, 7001, Australia; E-mail: john.bowman@utas.edu.au
Received: 27 November 2007 / Accepted: 14 December 2007 / Published: 18 December 2007